Controlling ambient oxygen levels reduces severity of GI GVHD in murine models

Seike K, Kiledal A, Fujiwara H, et al. Ambient Oxygen Levels Regulate Intestinal Dysbiosis and GVHD Severity After Allogeneic Stem Cell Transplantation. Immunity. 2023; 56 (2): 353 (doi: 10.1016/j.immuni.2023.01.007).

Researchers report that controlling ambient oxygen levels in the intestines may lessen the burden of graft-versus-host disease (GVHD) in allogeneic stem cell transplant recipients. The introduction of pathogenic T cells triggers intestinal damage in these patients. Based on murine models of gastrointestinal (GI) GVHD, scientists learned that this activity results in a loss of intestinal hypoxia in the GI tract. Subsequently, the gut microbiome is thrown into dysbiosis and the patient becomes more susceptible to acute disease. Researchers found that using oral iron chelation keeps intestinal ambient oxygen levels at appropriate levels and curtails the severity of GI GVHD.

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Tags: GVHD, transplantation, Cellular therapy, Research, Transplant, Graft versus host disease, grafts, graft, graft-versus-host disease, graft-versus-host