08.12.21

CRP Ferritin and EASIX Score predict CAR-T–related toxicities

Greenbaum U, Strati P, Saliba RM, et al. CRP and Ferritin in Addition to the EASIX Score Predict CAR-T–Related Toxicity. Blood Advances. 2021; 5 (14): 2799 (doi: 10.1182/bloodadvances.2021004575).

Use of the baseline Endothelial Activation and Stress Index (EASIX) score in conjunction with ferritin can predict chimeric antigen receptor (CAR)-T cell-related toxicity, according to a new study. Researchers prospectively collected toxicity data for 171 patients receiving axicabtagene ciloleucel treatment for large B-cell lymphoma (LBCL). Eighty-one patients (47%) developed cytokine release syndrome (CRS) grades 2-4 diagnoses and 84 (49%) were diagnosed with ICANS grades 2-4. The combination of EASIX plus ferritin (EASIX-F) identified three risk groups with CRS grades 2-4 cumulative incidence of 74% (hazards ratio [HR] 4.8), 49% (HR 2.3), and 23% (reference), respectively. The combination of EASIX plus CRP and ferritin (EASIX-FC) identified three risk groups with an ICANS grade 2-4 cumulative incidence of 74% (HR 3.6), 51% (HR 2.1), and 29% (reference), respectively. The results show how "common laboratory parameters” before lymphodepletion correlate with CAR-T–related toxicities and can help support clinical decisions, such as preemptive toxicity management, hospitalization length, and proper setting for CAR-T administration," the authors report.

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