Xiao Z, Alam IS, Simonetta F, et al. ICOS ImmunoPET Enables Visualization of Activated T Cells and Early Diagnosis of Murine Acute Gastrointestinal GVHD. Blood Advances. 2022; (doi: 10.1182/bloodadvances.2022007403).
Researchers identify noninvasive antibody-based PET (immunoPET) as a promising solution for predicting and diagnosing graft-versus-host disease (GVHD) early following allogeneic hematopoietic stem cell transplantation. While existing diagnostic strategies for GVHD are informed by clinical and pathological markers that typically present once the disease has already progressed to the advanced stages, immunoPET imaging of Inducible T-cell COStimulator (ICOS) could be significant. Using this technique, scientists were able to achieve in vivo visualization of donor T cell activation in the gastrointestinal tract of mice with acute GVHD. Specifically, researchers targeted ICOS with the 89Zr-DFO-ICOS monoclonal antibody PET tracer — which, importantly, does not affect GVHD pathogenesis or disrupt graft-versus-tumor activity mediated by the transplant procedure.