Impact of HSCT on VOEs requiring medical care SCD patients

Leonard AK, Furstenau D, Abraham AA, et al. Reduction in Vaso-Occlusive Events Following Stem Cell Transplantation in Patients with Sickle Cell Disease. Blood Advances. 2022; (doi: 10.1182/bloodadvances.2022008137).

Patients with sickle cell disease (SCD) who underwent hematopoietic stem cell transplantation (HSCT) saw significantly fewer vaso-occlusive events (VOEs) requiring medical care. Researchers compared the number of VOEs requiring medical attention that occurred in the two years prior to allogeneic HSCT to the number of VOEs following transplantation in 163 individuals with SCD whose average age was 21 years at the time of HSCT. In all, 75% (N=123) received non-myeloablative conditioning, and 72% (N=118) had a matched sibling donor. Mean VOE numbers fell from 5.6 in the two years before HSCT to 0.9 in the two years post-HSCT. Post-HSCT VOEs occurred more often in the first post-procedural year compared with the second (0.8 vs. 0.1). Among the 20 patients who had graft rejection, VOE numbers declined from 6.6 pre-HSCT to 1.1 and 0.8 in the first and second post-HSCT years, respectively.

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Tags: Patients, Treatment, hematopoietic, Research, sickle cell, impact, transplatation, hematopoietic transplantation, sickle cell disease, hematopoietic stem cell transplantation

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