Infusion of Memory T cells after haplo-HSCT

Van Beek JJP, Puccio S, Di Vito C, et al. Selected Memory T Cells Infused Post Haploidentical Hematopoietic Stem Cell Transplantation Persist and Hyper-Expand. Blood Advances. 2022; (doi: 10.1182/bloodadvances.2022007735).

New research shows that CD45RA-depleted donor lymphocyte infusions (DLI) in patients who have undergone haploidentical hematopoietic stem cell transplantation (haplo-HSCT) results in a substantial increase in certain infused memory T cell clones. The longitudinal analysis involved 19 haplo-HSCT patients who received post-transplant CD45RA-depleted DLI as part of a Phase II prospective clinical trial. According to T cell receptor sequencing analysis, the infusion of select donor memory T cells resulted in engraftment of pathogen-specific memory T cells, which persisted for at least a month. Most patients experienced strong polyfunctional effector cytomegalovirus-specific T cell responses. The cells' expansion corresponds with their frequency in the donor. Thus, the researchers report that there is a rational to suggest improved protection against viral infections for patients given CD45RA-depleted DLI.

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Tags: patient care, transplantation, Cellular therapy, Stem Cell, Research, cell therapy, T-Cell, researchers, responses, T cell, haploidentical-HCT, HaploHCT