11.17.22

Peripheral T helper cells in chronic GVHD

Kong X, Wu X, Wang B, et al. Trafficking Between Clonally Related Peripheral T Helper Cells and Tissue-Resident T Helper Cells in Chronic GVHD. Blood. 2022; (doi: 10.1182/blood.2022016581).

The intertwined activities of peripheral T helper (Tph) cells and pathogenic tissue-resident T helper (Trh) cells, which share certain T cell receptor a and ß repertoires, play a part in the pathogenesis of chronic graft-versus-host disease (cGVHD). Researchers report that expansion of Tph cells among CD4+ T cells in the blood of patients and mice with cGVHD, which correlates to more acute disease, is linked to the expansion of Trh cells that form lymphoid aggregates in GVHD target tissues. The results of adoptive transfer experiments reveal that Trh cells from GVHD target tissues promote the development and expansion of Tph cells in the blood, while Tph cells from the blood promote Trh cell development and growth in GVHD target tissues. However, the volume of both Tph cells in the blood and Trh cells in target tissues was significantly reduced in the absence of IL-21R-BCL6 signaling and T-bet in donor cells. This deficiency also limited T-B interaction in the lymphoid aggregates.

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