The STING protein pathway can protect certain patients from GVHD, according to a new study.
STING—or stimulator of interferon genes—is a signaling molecule associated with the endoplasmic reticulum and helps control the transcription of numerous host defense genes. Researchers—led by Robert Levy, PhD, from the University of Miami Miller School of Medicine—found in an animal model replicating an allogeneic transplant from a sibling match that when STING was absent, the symptoms of GVHD were reduced. When looking at STING in an unmatched transplant model, when it wasn’t there it made the GVHD worse.
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