06.30.22

Transplant Outcomes in Adults with HLH

Gooptu M, Kim HT, Jacobsen ED, et al. Favorable Outcomes Following Allogeneic Transplantation in Adults with Hemophagocytic Lymphohistiocytosis. Blood Advances. 2022; (doi: 10.1182/bloodadvances.2022007012).

New research suggests allogeneic hematopoietic stem-cell transplantation (HSCT) can negate the immune defect in hemophagocytic lymphohistiocytosis (HLH) when administered with a reduced intensity regimen involving early preconditioning using alemtuzumab. Researchers reviewed outcomes in a cohort of adult HLH patients transplanted starting in 2010. Patients were transplanted on a reduced intensity conditioning regimen involving early alemtuzumab infusion with standard infectious and graft-versus host disease (GVHD) prophylaxis. Overall survival (OS) was 75% at 3 years post-transplantation, while progression-free survival was 71%. The cumulative incidence (CI) of incidence of relapse at 3 years was 15%, with no isolated HLH relapses without malignancy relapse. The CI of non-relapse mortality at 3 years was 15%. Infectious complications and GVHD outcomes were similar to standard reduced intensity conditioning transplantation at the facility. Although it occurred frequently, mixed chimerism did not correspond with transplant outcomes.

Read More

Theme picker

Search